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Updated: Apr 24, 2026
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Association between GSTM1 null genotype and coronary artery disease risk: a meta-analysis
Background:
We conducted a meta-analysis to assess the association between polymorphisms of GSTM1 null genotype and coronary artery disease (CAD) risk.
Material And Methods:
Published literature from PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) were retrieved before March 2014. All studies reporting adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of CAD risk were included.
Results:
A total of 13 case-control studies, including 5453 cases and 5068 controls, were collected. There was a significant association between GSTM1 null genotype and CAD risk (adjusted OR=1.26; 95% CI, 1.11-1.43; I^2=3%). When stratified by ethnicity, a significantly elevated risk was observed in whites. In the subgroup analysis according to disease type, a significantly increased myocardial infarction (MI) risk was observed. Subgroup analysis of smoking status showed an increased CAD risk in smokers.
Conclusions:
Our results indicate that GSTM1 null genotype is associated with an increased CAD risk.