Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

377
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
377
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

350
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
350
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

849
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
849
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

392
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
392

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imaging-guided classification and diagnostic pathways for appendiceal abscesses: Results from the 2025 Italian Society of Research in Surgery/Italian Society of Emergency and Trauma Surgery consensus conference.

Surgery·2026
Same author

Appendiceal abscess: pathologic definitions and a diagnostic framework-SIRC/SICUT consensus.

International journal of colorectal disease·2026
Same author

Early hemodynamic changes following endoscopic sclerotherapy for hemorrhoidal disease assessed by transperineal ultrasound and their relationship with clinical outcomes.

International journal of colorectal disease·2026
Same author

Contemporary management pathways in liver trauma: predominant and successful use of non-operative strategies at a high-volume tertiary center.

Langenbeck's archives of surgery·2026
Same author

Milligan-Morgan hemorrhoidectomy, mucopexy, and hybrid combination for grade III hemorrhoids: a large retrospective cohort study.

Techniques in coloproctology·2026
Same author

Correction: Aligning perspectives: towards a standardized concept of "complexity" in thyroid surgery-an international web-based survey.

Updates in surgery·2026

Related Experiment Video

Updated: Apr 24, 2026

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

2.7K

Bloodless surgery in geriatric surgery.

Salvatore Guarino1, Filippo Maria Di Matteo1, Salvatore Sorrenti1

  • 1Department of Surgical Sciences, "Sapienza" University of Rome, Viale Regina Elena 324, 00161 Roma, Italy.

International Journal of Surgery (London, England)
|September 4, 2014
PubMed
Summary
This summary is machine-generated.

Bloodless surgery is feasible for geriatric Jehovah's Witness patients. Careful preoperative optimization and a multidisciplinary team approach are crucial for successful outcomes in this delicate population.

Keywords:
Bloodless surgeryElderly

More Related Videos

Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver
12:27

Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver

Published on: June 16, 2023

4.4K
A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia
12:40

A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia

Published on: September 28, 2022

1.9K

Related Experiment Videos

Last Updated: Apr 24, 2026

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

2.7K
Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver
12:27

Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver

Published on: June 16, 2023

4.4K
A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia
12:40

A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia

Published on: September 28, 2022

1.9K

Area of Science:

  • Medicine
  • Surgery
  • Geriatrics

Background:

  • Bloodless surgery aims to minimize perioperative transfusion needs.
  • Jehovah's Witnesses ethically decline blood transfusions.
  • Geriatric patients present unique physiological challenges for bloodless surgery due to slower response to decreased hemoglobin.

Purpose of the Study:

  • To describe a perioperative protocol for geriatric Jehovah's Witness patients undergoing bloodless surgery.
  • To highlight the feasibility and critical components of managing this patient group.

Main Methods:

  • Preoperative optimization of patients.
  • Intraoperative anesthetic and surgical management strategies.
  • Strict postoperative follow-up protocols.

Main Results:

  • Bloodless surgery is achievable in geriatric patients.
  • Specialized centers with multidisciplinary teams are essential.
  • Rigorous patient selection and preparation are mandatory.

Conclusions:

  • A tailored perioperative protocol enables successful bloodless surgery in geriatric Jehovah's Witnesses.
  • Multidisciplinary expertise and meticulous patient management are key to overcoming challenges in this population.