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Updated: Dec 31, 2025

High-Resolution Comparison of Bacterial Conjugation Frequencies
Published on: January 10, 2019
Type IV secretion systems and genomic islands-mediated horizontal gene transfer in Pseudomonas and Haemophilus
1Department of Pathology, University of Cambridge, Tennis Court Road, CB2 1QP Cambridge, UK.
Abstract:
Bacterial secretion systems, such as type IV secretion systems (T4SSs) are multi-subunit machines transferring macromolecules across membranes. Besides proteins, T4SSs also transfer nucleoprotein complexes, thus having a significant impact on the evolution of bacterial species. By T4SS-mediated horizontal gene transfer bacteria can acquire a broad spectrum of fitness genes allowing them to thrive in the wide variety of environments. Furthermore, acquisition of antibiotic-resistance and virulence genes can lead to the emergence of novel 'superbugs'. This review provides an update on the investigation of T4SSs. It highlights the role T4SSs play in the horizontal gene transfer, particularly in the evolution of catabolic pathways, antibiotic-resistance and virulence in Haemophilus and Pseudomonas.
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