Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioequivalence: Overview01:16

Bioequivalence: Overview

2.2K
Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
2.2K
Bioequivalence of Drugs: Drugs with Multiple Indications01:09

Bioequivalence of Drugs: Drugs with Multiple Indications

230
The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
230
Equivalence: In Vitro and In Vivo Bioequivalence01:17

Equivalence: In Vitro and In Vivo Bioequivalence

383
Bioequivalence studies are crucial in evaluating whether new drugs can match an approved one regarding pharmacological effects and clinical performance. These studies test if drugs, despite different dosage forms, share identical plasma concentration-time profiles. Three types of equivalence are central to these studies: chemical, pharmaceutical, and therapeutic. Chemical equivalence indicates that two or more drug products contain identical active ingredients in equal amounts. Pharmaceutical...
383
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

407
Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to subjects...
407
Bioequivalence Data: Statistical Interpretation01:16

Bioequivalence Data: Statistical Interpretation

354
The statistical interpretation of bioequivalence data is a significant aspect of pharmaceutical research. Bioequivalence refers to the absence of any significant difference in the rate and extent to which the active ingredient in pharmaceutical products becomes available at the site of drug action when administered at the same molar dose under similar conditions. This helps determine if different drug products have similar absorption rates, ensuring their interchangeability.Statistical...
354
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

413
Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
413

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adaptation of quality control pipeline for Skeletal Muscle 31P MR Spectroscopy at 3T and 7T.

Zeitschrift fur medizinische Physik·2026
Same author

Analysis of EURADOS neutron intercomparison results according to new ISO standards criteria.

Radiation protection dosimetry·2023
Same author

Acute responses of hepatic fat content to consuming fat, glucose and fructose alone and in combination in non-obese non-diabetic individuals with non-alcoholic fatty liver disease.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2021
Same author

CHARACTERISATION OF RADIOPHOTOLUMINESCENCE DOSIMETRY SYSTEM FOR INDIVIDUAL MONITORING.

Radiation protection dosimetry·2020
Same author

Determination of antimicrobial activity of Achatina reticulata slime.

Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne·2019
Same author

Clinical and (31)P magnetic resonance spectroscopy characterization of patients with critical limb ischemia before and after autologous cell therapy.

Physiological research·2019
Same journal

A proposal for a differentiated radiation protection program for the decommissioning of nuclear power plants compared to the operation of nuclear power plants.

Radiation protection dosimetry·2026
Same journal

A three-dimensional neutron localization method based on double-scattering imaging and reconstruction algorithm.

Radiation protection dosimetry·2026
Same journal

Effect of 131I biodistribution on measurements using a scanning whole-body counter.

Radiation protection dosimetry·2026
Same journal

Activity concentration of 137Cs and natural radionuclides in soil around the Belarusian nuclear power plant in the pre-commissioning period.

Radiation protection dosimetry·2026
Same journal

Novel passive-adaptive exoskeleton-supported radiation protection equipment with enhanced shielding and reduced perceived weight.

Radiation protection dosimetry·2026
Same journal

Feasibility of kV dose measurement in IGRT using MV-calibrated ionization chambers.

Radiation protection dosimetry·2026
See all related articles

Related Experiment Video

Updated: Apr 24, 2026

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

4.6K

Developments and trends in bioequivalent dosimetry.

M Hajek1

  • 1Radiation Safety Technical Services Unit, Division of Radiation, Transport and Waste Safety, International Atomic Energy Agency, Vienna 1400, Austria m.hajek@iaea.org.

Radiation Protection Dosimetry
|September 4, 2014
PubMed
Summary
This summary is machine-generated.

Microdosimetry advances radiobiology by focusing on cellular-level radiation effects. This microscopic approach, using nanometre-scale analysis, refines radiation protection and biological effectiveness evaluation.

More Related Videos

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.4K
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

19.7K

Related Experiment Videos

Last Updated: Apr 24, 2026

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

4.6K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.4K
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

19.7K

Area of Science:

  • Radiobiology
  • Radiation Physics
  • Radiation Protection

Background:

  • Traditional macroscopic dosimetry is being challenged by a microscopic approach in radiobiology.
  • Understanding radiation-induced biological responses at the cellular level is crucial.
  • The stochastic nature of energy deposition at cellular scales necessitates new dosimetry methods.

Purpose of the Study:

  • To highlight the shift towards a microscopic approach in understanding radiation action.
  • To emphasize the role of microdosimetry and nanometre-scale phenomena in radiobiology.
  • To introduce bioequivalent dosimetry as a method for evaluating biological effectiveness.

Main Methods:

  • Investigating the stochastics of energy deposition in cellular-sized volumes.
  • Utilizing Monte Carlo track structure simulations in radiobiology.
  • Employing physical detectors to measure ionisation clusters at nanometre scales.

Main Results:

  • Evidence suggests critical biological targets are in the nanometre regime.
  • Microdosimetry has emerged as a distinct scientific discipline.
  • Bioequivalent dosimetry links physical detector responses to biological endpoints.

Conclusions:

  • A microscopic approach is essential for accurate dosimetry in radiobiology.
  • Nanometre-scale energy deposition is key to understanding biological effects.
  • Bioequivalent dosimetry aids in developing new radiation protection quantities for evaluating biological effectiveness irrespective of dose and dose rate.