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Updated: Apr 24, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Advances in autosomal dominant polycystic kidney disease-2014 and beyond

William E Braun1

  • 1Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, one of seven US centers participating in the HALT-PKD collaborative study braunw@ccf.org.

Cleveland Clinic Journal of Medicine
|September 4, 2014
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) lacks specific treatments, often progressing to end-stage renal disease. Recent research improves diagnosis and identifies promising new therapeutic strategies for ADPKD.

Area of Science:

  • Nephrology
  • Genetics
  • Pharmacology

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder.
  • ADPKD frequently results in end-stage renal disease (ESRD).
  • Current therapeutic options for ADPKD are limited, lacking specific disease-modifying drugs.

Purpose of the Study:

  • To review recent advancements in understanding ADPKD pathogenesis.
  • To discuss progress in diagnostic accuracy for ADPKD.
  • To highlight emerging therapeutic strategies and clinical trial outcomes for ADPKD.

Main Methods:

  • Literature review of recent studies on ADPKD.
  • Analysis of clinical trial data for ADPKD treatments.
  • Synthesis of information on ADPKD diagnosis and management.

Main Results:

  • Improved understanding of ADPKD molecular mechanisms.
  • Enhanced diagnostic tools for identifying ADPKD and its complications.
  • Identification of several promising drug candidates and therapeutic approaches in clinical trials.

Conclusions:

  • Despite challenges, significant progress has been made in ADPKD research.
  • New diagnostic and therapeutic avenues offer hope for ADPKD patients.
  • Further research and clinical trials are crucial for developing effective ADPKD treatments.

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