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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Updated: Apr 24, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Modeling cutaneous squamous carcinoma development in the mouse.

Phillips Y Huang¹, Allan Balmain¹

¹Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158.

Cold Spring Harbor Perspectives in Medicine

|September 4, 2014

Summary

This study explores the classic mouse model for cutaneous squamous cell carcinoma (SCC) development. Understanding these skin cancer mechanisms in mice offers insights for human treatment and prevention strategies.

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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

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Published on: December 19, 2019

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Last Updated: Apr 24, 2026

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Published on: June 7, 2019

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

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Published on: April 22, 2019

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

Area of Science:

Oncology
Dermatology
Cancer Biology

Background:

Cutaneous squamous cell carcinoma (SCC) is a prevalent cancer in Caucasian populations, posing significant health risks.
The two-stage chemical carcinogenesis mouse model is crucial for understanding multistage carcinogenesis in both human and mouse cancers.
Key factors influencing SCC development include genetic mutations, target cell origins, and inflammation.

Purpose of the Study:

To review the current understanding of biological and genetic events in mouse skin carcinogenesis.
To highlight the role of oncogene/tumor-suppressor pathways, target cells, and inflammation in SCC development.
To emphasize the translational potential of mouse skin cancer models for human squamous malignancy treatment and chemoprevention.

Main Methods:

Review of established two-stage chemical carcinogenesis protocols in mice.
Analysis of molecular and cellular events during skin tumor development.
Examination of factors modulating tumor progression and metastasis.

Main Results:

Detailed knowledge exists regarding the sequence of genetic and biological events in mouse skin SCC.
Specific signaling pathways, initial target cells, and inflammatory processes are identified as critical modulators.
Mouse models provide a platform for studying tumor-initiating cells and malignant progression.

Conclusions:

Mouse skin cancer models are invaluable for dissecting the complexities of carcinogenesis.
Insights gained from these models can guide the development of novel therapeutic and preventative strategies for human SCC.
Further research into tumor-initiating cells and metastasis in these models holds significant promise.