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Updated: Apr 24, 2026

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
Effect of intermittent subglottic secretion drainage on ventilator-associated pneumonia: A clinical trial
Rahimeh Safdari1, Ahmadreza Yazdannik1, Saeed Abbasi2
1Department of Critical Care Nursing, Nursing and Midwifery School, Isfahan, Iran.
Background:
Secretions contaminated with oral, nasal, and gastric bacteria accumulate in the subglottic space, above the endotracheal tube cuff. If these secretions are aspirated into lower airways, the intubated patient will be susceptible to ventilator-associated pneumonia (VAP). The aim of this study was to investigate the effect of inspiratory pause maneuver for intermittent subglottic secretions drainage (SSD) on the incidence of VAP in patients receiving mechanical ventilation.
Materials And Methods:
This randomized clinical trial was conducted in four intensive care units of educational hospital in Isfahan, Iran. A total of 76 adult patients intubated with a conventional endotracheal tube and connected to ventilators for more than 48 h were selected through convenient sampling and were randomly assigned to undergo intermittent SSD (n = 38) or not (n = 38). In this study, for SSD, we used inspiratory pause/hold key in the ventilators to hyperinflate the lungs. Pressure that produces with this maneuver could remove the secretions from the subglottic space.
Results:
VAP was found in 10 (26.3%) patients receiving SSD and in 18 (47.4%) patients in the control group (P = 0.04).
Conclusions:
SSD using inspiratory pause during mechanical ventilation results in a significant reduction in VAP.
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