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Related Concept Videos

Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Related Experiment Video

Updated: Apr 24, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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SRC: marker or actor in prostate cancer aggressiveness.

Virginie Vlaeminck-Guillem1, Germain Gillet2, Ruth Rimokh2

  • 1University of Lyon, Cancer Research Centre of Lyon, U1052 INSERM, UMS 3453 CNRS, Lyon I University, Léon Bérard Centre , Lyon , France ; Medical Unit of Molecular Oncology and Transfer, Department of Biochemistry and Molecular Biology, University Hospital of Lyon-Sud, Hospices Civils of Lyon , Lyon , France.

Frontiers in Oncology
|September 4, 2014
PubMed
Summary

Identifying aggressive prostate cancer (PCa) is crucial for treatment. Src kinase family members are potential markers for PCa aggressiveness and progression.

Keywords:
SFK familyaggressivenessc-Srcepithelial-to-mesenchymal transitionneuroendocrine differentiationprognosisprostate cancertyrosine-kinase

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Area of Science:

  • Urologic oncology
  • Molecular oncology
  • Cancer biology

Background:

  • Distinguishing aggressive from indolent prostate cancer (PCa) is critical for effective patient management.
  • Current diagnostic methods lack reliable markers to predict PCa aggressiveness.
  • The molecular drivers of PCa aggressiveness remain poorly understood.

Purpose of the Study:

  • To review the role of the Src kinase family in prostate cancer (PCa) progression and aggressiveness.
  • To explore Src as a potential marker for identifying aggressive PCa.
  • To understand the molecular mechanisms linking Src to PCa aggressiveness.

Main Methods:

  • Literature review of studies investigating Src kinase family members in PCa.
  • Analysis of molecular pathways influenced by Src in cancer progression.
  • Examination of Src's involvement in cellular events related to tumor aggressiveness.

Main Results:

  • Src kinase family activation is frequently observed in PCa.
  • Src influences key pathways (e.g., AR, TGFbeta, Akt) involved in tumor progression.
  • Src impacts cell proliferation, invasion, metastasis, and resistance to apoptosis in PCa.

Conclusions:

  • The Src kinase family is a significant factor in prostate cancer (PCa) aggressiveness.
  • Src activation correlates with advanced tumor characteristics and metastatic potential.
  • Targeting Src may offer a strategy for managing aggressive PCa.