Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene-Environment Interactions01:20

Gene-Environment Interactions

1.4K
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
1.4K
Epigenetic Regulation01:37

Epigenetic Regulation

3.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.3K
Epigenetic Regulation01:46

Epigenetic Regulation

28.6K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
28.6K
Epigenetic Regulation01:46

Epigenetic Regulation

24.0K
24.0K
Hypoxia01:23

Hypoxia

2.4K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
2.4K
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

5.8K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Objective verification of continuous speech sound discrimination using the acoustic change complex.

Frontiers in human neuroscience·2026
Same author

Modification of internal RNA domains from the long non-coding RNA XIST refines roles in silencing and heterochromatin recruitment.

Human molecular genetics·2026
Same author

Impact of somatic XIST deletions on ongoing XIST expression and inactive X silencing and heterochromatin.

Human molecular genetics·2025
Same author

Escape from X-chromosome inactivation at KDM5C is driven by promoter-proximal DNA elements and enhanced by domain context.

Human molecular genetics·2025
Same author

Breaking rules: the complex relationship between DNA methylation and X-chromosome inactivation in the human placenta.

Biology of sex differences·2025
Same author

Recruitment of chromatin remodelers by XIST B-repeat region is variably dependent on HNRNPK.

Human molecular genetics·2024

Related Experiment Video

Updated: Apr 24, 2026

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
09:13

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice

Published on: July 11, 2025

26.7K

Hypoxia and environmental epigenetics.

Carolyn J Brown1, James L Rupert

  • 11 Department of Medical Genetics, Molecular Epigenetics Group, University of British Columbia , Vancouver, British Columbia, Canada .

High Altitude Medicine & Biology
|September 4, 2014
PubMed
Summary
This summary is machine-generated.

Epigenetics involves heritable gene modifications independent of DNA sequence changes. These dynamic epigenetic marks regulate gene expression and influence organismal adaptation to environmental factors like hypoxia.

Keywords:
DNA methylationaltitudechromatingene regulationhistone modifications

More Related Videos

Induction and Testing of Hypoxia in Cell Culture
07:01

Induction and Testing of Hypoxia in Cell Culture

Published on: August 12, 2011

88.2K
Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
09:17

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions

Published on: August 2, 2018

17.4K

Related Experiment Videos

Last Updated: Apr 24, 2026

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
09:13

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice

Published on: July 11, 2025

26.7K
Induction and Testing of Hypoxia in Cell Culture
07:01

Induction and Testing of Hypoxia in Cell Culture

Published on: August 12, 2011

88.2K
Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
09:17

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions

Published on: August 2, 2018

17.4K

Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • Epigenetics describes heritable gene activity modifications not altering DNA sequence.
  • These involve chemical changes to DNA and associated proteins, forming chromatin.
  • Epigenetic marks regulate gene accessibility for transcription factors, influencing gene expression and phenotype.

Purpose of the Study:

  • To explore the role of epigenetics in gene regulation.
  • To understand how epigenetic modifications are transmitted through cell and organismal generations.
  • To investigate the implications of epigenetic reprogramming for acclimatization and adaptation, particularly to hypoxia.

Main Methods:

  • Analysis of DNA and protein modifications within chromatin structure.
  • Investigation of epigenetic mark inheritance through mitosis and meiosis.
  • Examination of tissue-specific epigenetic information dynamics in response to environmental stimuli.

Main Results:

  • Epigenetic modifications dynamically regulate gene expression and phenotype.
  • Differential gene expression patterns are transmitted across cell generations via mitosis.
  • Epigenetic cues can be maintained through meiosis, enabling transgenerational inheritance.
  • Epigenetic information is tissue-specific and responsive to environmental changes.

Conclusions:

  • Epigenetics provides a mechanism for rapid, adaptive gene expression optimization.
  • The capacity for epigenetic reprogramming impacts understanding of acclimatization and adaptation.
  • Epigenetic mechanisms are crucial for organisms to respond to and prepare for environmental challenges like hypoxia.