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Related Concept Videos

Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Apr 24, 2026

Capture and Release of Viable Circulating Tumor Cells from Blood
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Capture and Release of Viable Circulating Tumor Cells from Blood

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CTCs could guide cancer therapy

    Cancer Discovery
    |September 4, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Scientists captured circulating tumor cells using a microchip for genetic analysis. This approach identified novel tumor mutations responsive to targeted therapies, advancing cancer treatment strategies.

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    Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

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    Area of Science:

    • Oncology
    • Biotechnology
    • Genetics

    Background:

    • Circulating tumor cells (CTCs) are crucial biomarkers for cancer progression and treatment response.
    • Current methods for CTC isolation and analysis present challenges in efficiency and scalability.

    Purpose of the Study:

    • To develop and validate a microchip-based platform for capturing and culturing CTCs.
    • To enable comprehensive genetic analysis and drug sensitivity testing on viable CTCs.

    Main Methods:

    • A novel microfluidic device was employed for the enrichment and isolation of CTCs from patient samples.
    • Captured CTCs were cultured in vitro to generate sufficient cell numbers for downstream analyses.
    • High-throughput sequencing and targeted drug screening assays were performed on the cultured CTCs.

    Main Results:

    • The microchip device successfully captured and cultured viable CTCs, preserving their genetic integrity.
    • New tumor-specific mutations were identified, revealing previously unknown driver alterations.
    • Drug testing demonstrated that identified mutations were susceptible to specific targeted therapeutic agents.

    Conclusions:

    • Microchip-based CTC capture and culture offer a powerful tool for personalized cancer medicine.
    • This technology facilitates the discovery of actionable tumor mutations and guides targeted therapy selection.
    • The platform holds significant potential for improving patient outcomes through precision oncology.