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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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Published on: October 15, 2019

[Intestinal microorganisms and allergic diseases].

Fengling Yang, Yu Zhao

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery

|September 5, 2014

Summary

The hygiene hypothesis suggests gut microbes impact immune homeostasis, influencing allergic disease development. Understanding these gut microbiome-immune interactions may lead to new allergy treatments.

Area of Science:

Microbiology
Immunology
Allergology

Context:

The 'hygiene hypothesis' proposes a link between reduced microbial exposure and increased allergic diseases.
Intestinal microbes play a crucial role in regulating both local immune status and systemic immune homeostasis.
Alterations in gut microbiota composition are increasingly implicated in the pathogenesis of allergic conditions.

Purpose:

To investigate the complex relationships among intestinal microbes, the immune system, and allergic diseases.
To explore how factors influencing gut microorganisms impact immune homeostasis and allergy risk.
To provide a foundation for developing novel therapeutic interventions for allergic diseases.

Summary:

This review examines the intricate connections between the gut microbiome, immune system function, and the development of allergic diseases.

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Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

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Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

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Published on: November 17, 2018

It highlights how environmental and lifestyle factors affecting gut microbial communities can disrupt immune balance, potentially leading to allergies.

The interplay between intestinal microbes and immune homeostasis is presented as a key factor in allergic disease pathogenesis.

Impact:

Findings may elucidate the mechanisms underlying the hygiene hypothesis in relation to allergies.
Understanding the gut microbiome's role in immune regulation could identify novel biomarkers for allergy risk.
This research could inform the development of microbiome-targeted strategies for preventing and treating allergic diseases.