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Effect of curcumin on rats/mice with diabetic nephropathy: a systematic review and meta-analysis of randomized
Objective:
To assess the renal protective effects of curcumin administration on diabetic rats/mice.
Methods:
Databases were searched electronically and conference papers searched manually for search terms to find relevant studies. Articles were assessed independently by two reviewers. Review Manager 5.1 was used for data analysis.
Results:
Fourteen randomized controlled experiments were included. Meta-analysis demonstrated that blood sugar levels and kidney weight to body weight ratios in the model group were higher than those in the normal group, and the curcumin group had significantly lower mesangial area to glomerular area ratios compared with the model group, and also lower levels of urinary protein, blood urea nitrogen and serum creatinine.
Conclusion:
Curcumin shows protective effects on the kidneys of rats/mice with diabetes.
Insights
Curcumin administration demonstrated significant renal protective effects in diabetic rats and mice. It helped lower blood sugar, kidney weight, and markers of kidney damage like urinary protein.
Area of Science:
- Nephrology
- Endocrinology
- Pharmacology
Background:
- Diabetic nephropathy is a major complication of diabetes mellitus.
- Identifying effective therapeutic agents to protect kidney function in diabetes is crucial.
Purpose of the Study:
- To evaluate the renoprotective potential of curcumin in diabetic animal models.
- To synthesize evidence from randomized controlled trials on curcumin's effects on kidney parameters in diabetes.
Main Methods:
- Systematic literature search of electronic databases and manual search of conference papers.
- Independent assessment of retrieved articles by two reviewers.
- Meta-analysis of data from fourteen randomized controlled experiments using Review Manager 5.1.
Main Results:
- Meta-analysis confirmed elevated blood glucose and kidney-to-body weight ratios in diabetic models compared to controls.
- Curcumin administration significantly reduced mesangial area to glomerular area ratios.
- Curcumin treatment led to lower levels of urinary protein, blood urea nitrogen, and serum creatinine.
Conclusions:
- Curcumin exhibits significant renoprotective properties in diabetic rats and mice.
- The findings support curcumin as a potential therapeutic agent for preventing or mitigating diabetic nephropathy.
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