Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

42.8K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
42.8K
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

55
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
55
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

156
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
156

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulating the Swelling Behavior of Polymer Brushes via Interfacial Chemistry.

Angewandte Chemie (International ed. in English)·2026
Same author

Plant-Growth Synchronized, Acid Phosphatase-Responsive Lignin-Based Controlled Release Phosphorus Nanofertilizers.

Biomacromolecules·2026
Same author

Sustainable thermal paper formulation using lignocellulosic biomass fractions.

Science advances·2026
Same author

Orthogonally Functionalizable Redox-Responsive Polymer Brushes: Catch and Release Platform for Proteins and Cells.

Journal of the American Chemical Society·2025
Same author

Supramolecular Polymer Brushes Grafted via Atom Transfer Radical Polymerization from Surfaces Presenting Non-covalent, Host-Guest Complex-Based Initiators.

Macromolecules·2025
Same author

Biodegradable Polymers for Plant Nutrient Delivery and Recovery.

Macromolecular bioscience·2025

Related Experiment Video

Updated: Apr 24, 2026

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
12:03

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy

Published on: September 5, 2016

7.0K

Polymeric anti-HIV therapeutics.

Maarten Danial1, Harm-Anton Klok

  • 1École Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères Bâtiment MXD, Station 12, Lausanne, CH-1015, Switzerland. Maarten.Danial@csiro.au.

Macromolecular Bioscience
|September 5, 2014
PubMed
Summary

Polymer therapeutics offer a promising strategy to combat human immunodeficiency virus (HIV) infection. This review details various polymeric agents designed to inhibit HIV replication and transmission.

Keywords:
HIV polymer therapeuticsantiviralinhibitormicrobicidepolyvalency

More Related Videos

Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
13:47

Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery

Published on: June 23, 2011

19.0K
Engineering Antiviral Agents via Surface Plasmon Resonance
13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.2K

Related Experiment Videos

Last Updated: Apr 24, 2026

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
12:03

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy

Published on: September 5, 2016

7.0K
Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
13:47

Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery

Published on: June 23, 2011

19.0K
Engineering Antiviral Agents via Surface Plasmon Resonance
13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.2K

Area of Science:

  • Polymer Science and Nanotechnology
  • Virology and Infectious Diseases
  • Drug Delivery and Therapeutics

Background:

  • Human immunodeficiency virus (HIV) remains a significant global health challenge.
  • Current antiretroviral therapies target critical steps in the HIV life cycle.
  • There is a continuous need for novel therapeutic strategies to combat HIV.

Purpose of the Study:

  • To review the application of polymer therapeutics in curbing HIV transmission and infection.
  • To provide a comprehensive overview of polymeric anti-HIV agents and their properties.
  • To discuss the potential of these agents as systemic and topical therapeutics.

Main Methods:

  • Review of the HIV life cycle and existing antiretroviral drugs.
  • Analysis of the structure and inhibitory properties of various polymeric anti-HIV agents.
  • Exploration of different polymer-based therapeutic platforms including polysaccharides, synthetic polymers, dendrimers, and conjugates.

Main Results:

  • Detailed examination of polymeric inhibitors, including polysaccharide-based, synthetic polymer-based, dendritic polymer-based, and polymer conjugate-based agents.
  • Presentation of polymeric DC-SIGN antagonists as a class of inhibitors.
  • Discussion of the diverse structural features and inhibitory mechanisms of these agents.

Conclusions:

  • Polymer therapeutics demonstrate significant potential for developing novel anti-HIV strategies.
  • Various polymer-based approaches, including systemic and topical applications, show promise in controlling HIV.
  • Further research into polymer therapeutics could lead to more effective HIV prevention and treatment options.