Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:09

Cell Migration

16.6K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
16.6K
Cell Migration01:19

Cell Migration

6.0K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.0K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

5.0K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
5.0K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

2.8K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.8K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

4.8K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.8K
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.7K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conserved and Lineage-Specific Roles of KEA-Mediated Ion Homeostasis in Chlamydomonas.

Plant physiology·2026
Same author

Mechanics and thermodynamics of the living cell, dedicated to Erich Sackmann.

Biophysical journal·2026
Same author

Effect of very long-chain lipids on the organization of biological membranes: A simulation study.

Biophysical journal·2026
Same author

Pattern Formation Beyond Turing: Physical Principles of Mass-Conserving Reaction-Diffusion Systems.

Annual review of biophysics·2026
Same author

Coarsening dynamics of chemotactic aggregates.

Physical review. E·2025
Same author

Chemotaxis-Induced Phase Separation.

Physical review letters·2025
Same journal

Heterogeneous binding of SARS-CoV2 fusion peptide on complex cellular membranes enhances its fusogenicity.

Biophysical journal·2026
Same journal

Tau protein differentially affects Piezo1 and Kir2.1 channels in brain capillary endothelial cells.

Biophysical journal·2026
Same journal

Emergent Intercellular Junction Stability during Cyclic Tissue Loading.

Biophysical journal·2026
Same journal

Enhanced-Sampling Simulations Reveal Distinct Intermediates in SARS-CoV-2 FSE Pseudoknot Interconversion.

Biophysical journal·2026
Same journal

Structure-based simulations of the full Flock House virus capsid reveal pathways and energetics of an infection-critical peptide externalization event.

Biophysical journal·2026
Same journal

Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

Biophysical journal·2026
See all related articles

Related Experiment Video

Updated: Apr 24, 2026

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

11.5K

Flow and diffusion in channel-guided cell migration.

Anna-Kristina Marel1, Matthias Zorn2, Christoph Klingner3

  • 1Fakultät für Physik, Ludwig Maximilians Universität, München, Germany; Center for NanoScience, Ludwig Maximilians Universität, München, Germany; Nanosystems Initiative Munich, München, Germany.

Biophysical Journal
|September 5, 2014
PubMed
Summary
This summary is machine-generated.

Collective cell migration in microchannels forms a directed current with velocity gradients. This flow is driven by directed migration and density-dependent diffusion, impacting cell motility and reducing swirl formation.

More Related Videos

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

11.7K
Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

7.9K

Related Experiment Videos

Last Updated: Apr 24, 2026

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

11.5K
Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

11.7K
Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

7.9K

Area of Science:

  • Cell biology
  • Biophysics
  • Mechanobiology

Background:

  • Collective cell migration is crucial for development and disease.
  • Epithelial sheet dynamics are complex, showing heterogeneity and arrest.
  • Flow properties in confined geometries remain poorly understood.

Purpose of the Study:

  • Investigate short- and long-term cell flow in microchannels.
  • Characterize velocity profiles and contributing factors.
  • Understand how large-scale flow affects individual cell behavior.

Main Methods:

  • Single-cell tracking
  • Particle image velocimetry (PIV)
  • Analysis of cell trajectories and vorticity

Main Results:

  • A stationary cell current with velocity gradients and plug-flow profiles emerged.
  • Flow velocity comprises directed migration and density-gradient-dependent diffusion.
  • Channel flow reduced swirl formation and induced persistent, long-range random-walk behavior in cells.

Conclusions:

  • Cell migration in channels exhibits directed drift and diffusion-mediated transport.
  • Active cell migration influences cellular motility at short length scales.
  • Findings provide insights into collective cell movement in confined environments.