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Updated: Apr 24, 2026
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A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
Published on: May 3, 2021
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Glucocorticoid receptor DNA binding factor 1 expression and osteosarcoma prognosis
Jinmin Zhao1, Hua Xu, Maolin He
1Department of Orthopedic Trauma and Hand Surgery, Research Center for Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Rd., Nanning, Guangxi, China.
Summary
High Glucocorticoid receptor DNA binding factor 1 (GRF-1) expression indicates a poor prognosis in osteosarcoma patients. GRF-1 is identified as an independent prognostic factor, suggesting it as a potential therapeutic target for osteosarcoma.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Glucocorticoid receptor DNA binding factor 1 (GRF-1), a Rho family GTPase-activating protein, has dysregulated expression implicated in tumor progression.
- The prognostic significance of GRF-1 expression in osteosarcoma remains underexplored.
Purpose of the Study:
- To investigate the association between GRF-1 expression levels and the prognosis of osteosarcoma.
- To determine if GRF-1 is an independent prognostic factor in osteosarcoma.
Main Methods:
- A hospital-based case study involving 247 patients with pathologically confirmed osteosarcoma.
- Analysis of GRF-1 expression and its correlation with clinical outcomes, including recurrence-free survival (RFS) and overall survival (OS).
- Evaluation of GRF-1 expression in relation to tumor characteristics like size, differentiation, and metastasis.
Main Results:
- High GRF-1 expression was significantly correlated with poorer osteosarcoma outcomes (median RFS: 11 months vs. 56 months; median OS: 18 months vs. 53 months).
- GRF-1 expression was an independent prognostic factor for both RFS (HR: 5.39) and OS (HR: 6.58), similar to tumor stage.
- High GRF-1 expression associated with larger tumor size, dedifferentiation, and increased metastasis risk. Knockdown of GRF-1 inhibited proliferation and induced apoptosis in tumor cells.
Conclusions:
- GRF-1 expression is a significant independent prognostic factor for osteosarcoma.
- High GRF-1 expression is linked to aggressive tumor features and poor patient outcomes.
- GRF-1 represents a potential therapeutic target for improving osteosarcoma prognosis.
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