Development of a therapeutic hypothermia protocol: implementation for postcardiac arrest STEMI patients
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Updated: Apr 24, 2026

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
Mari-Newton Dixon1, Michelle Keasling
1Cape Fear Valley Health System, Fayetteville, North Carolina.
Insights
Implementing therapeutic hypothermia (TH) for ST-segment elevated myocardial infarction (STEMI) patients after cardiac arrest improves postresuscitation care. This quality improvement initiative established a crucial TH protocol at Cape Fear Valley Medical Center.
Area of Science:
- Cardiology
- Critical Care Medicine
- Quality Improvement
Background:
- Therapeutic hypothermia (TH) is proven to reduce neurologic injury and mortality in cardiac arrest survivors.
- ST-segment elevated myocardial infarction (STEMI) is a common cause of cardiac arrest, with primary percutaneous coronary intervention (PCI) as the recommended initial treatment.
- Cape Fear Valley Medical Center (CFVMC) lacked a TH protocol for STEMI patients, creating a gap in evidence-based postresuscitation care.
Purpose of the Study:
- To develop and implement a therapeutic hypothermia (TH) protocol for STEMI patients presenting after out-of-hospital cardiac arrest at CFVMC.
- To integrate TH into the existing STEMI treatment pathway, enhancing care for this specific patient population.
- To address a critical need for standardized, evidence-based postresuscitation care at a PCI-capable center.
Main Methods:
- Adapted the existing STEMI process to incorporate TH for postcardiac arrest STEMI patients.
- Developed a TH STEMI flow map, reallocated nursing staff, and explored cooling methods and equipment.
- Created an evidence-based physician order set, nursing documentation, competency assessments, and conducted educational sessions.
Main Results:
- Successfully developed and implemented a comprehensive TH protocol for postcardiac arrest STEMI patients.
- The protocol involved multiple disciplines and required extensive committee approvals.
- Physician and nursing knowledge gaps were identified as the primary implementation challenge.
Conclusions:
- The established TH protocol represents a significant advancement in evidence-based practice for postresuscitation care.
- This initiative improves the quality of care for STEMI patients experiencing cardiac arrest.
- The protocol provides a framework for standardized TH implementation in similar clinical settings.
Abstract:
Therapeutic hypothermia (TH) reduces neurologic injury and mortality in out-of-hospital cardiac arrest survivors. Myocardial infarction (MI) is one of the main causes of cardiac arrest and primary percutaneous coronary intervention (PCI) is recommended as initial treatment for patients who present with acute ST-segment elevated MI (STEMI). Cape Fear Valley Medical Center (CFVMC) was the only designated PCI center in the state of North Carolina without a TH protocol. The purpose of this quality improvement initiative was to develop and implement a TH protocol for postcardiac arrest STEMI patients at CFVMC. The existing STEMI process was adapted to include the use of TH for STEMI patients who presented from out-of-hospital cardiac arrest. Steps to development of the protocol included creation of TH STEMI flow map, reallocation of nursing staff, exploration of cooling methods and equipment options, development of a evidence-based physician order set, creation of nursing documentation process and competency assessment, organization of educational sessions, and approval through multiple hospital committees. The development of a postarrest STEMI TH protocol involved multiple disciplines and required approval from several committees. Lack of physician and nursing knowledge of the protocol proved to be the greatest challenge. The TH protocol is a step forward in implementing evidence-based practice and improving the quality of postresuscitation care provided to postcardiac arrest STEMI patients.
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