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Updated: Apr 24, 2026
Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers
Published on: March 8, 2012
Capturing glimpses of an elusive HIV gp41 prehairpin fusion intermediate
Lukas K Tamm1, Jinwoo Lee1, Binyong Liang1
1Center for Membrane Biology and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Abstract:
Nuclear magnetic resonance (NMR) studies on an HIV gp41 construct reported by Lakomek and colleagues in this issue of Structure have revealed the conformational dynamics of a possible trimeric prehairpin fusion intermediate and its interactions with lipids. Two alternative fusion pathways are compared based on this work and a previous NMR structure of a monomeric lipid-bound gp41 ectodomain construct.
