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Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
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In vivo P-glycoprotein function before and after epilepsy surgery

Martin Bauer1, Rudolf Karch1, Markus Zeitlinger1

  • 1From the Departments of Clinical Pharmacology (M.B., M.Z., M. Müller, O.L.) and Neurology (E.P.), Center for Medical Statistics, Informatics, and Intelligent Systems (R.K.), Institute of Neurology (J.A.H.), and Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine (W.W., M. Mitterhauser), Medical University of Vienna, Austria; Department of Clinical and Experimental Epilepsy (J.L., M.J.K., S.M.S.), UCL Institute of Neurology, London; Epilepsy Society (M.J.K., S.M.S.), Chalfont St Peter, Buckinghamshire; Institute for Population Health Wolfson Molecular Imaging Centre (M.-C.A.), University of Manchester, MAHSC, UK; and Health and Environment Department (O.L.), AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.

Neurology
|September 5, 2014
PubMed
Summary

P-glycoprotein (Pgp) overactivity in temporal lobe epilepsy patients is dynamic. Seizure freedom after surgery correlates with reduced Pgp function, suggesting Pgp activity reversal is key for optimal epilepsy treatment.

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