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A mononuclear manganese(II) complex demonstrates a strategy to simultaneously image and treat oxidative stress
Meng Yu1, Stephen L Ambrose, Zachary L Whaley
1Department of Chemistry and Biochemistry, ‡Magnetic Resonance Imaging Research Center, and §Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University , Auburn, Alabama 36849, United States.
Abstract:
A manganese(II) complex with a ligand containing an oxidizable quinol group serves as a turn-on sensor for H2O2. Upon oxidation, the relaxivity of the complex in buffered water increases by 0.8 mM(-1) s(-1), providing a signal that can be detected and quantified by magnetic resonance imaging. The complex also serves as a potent antioxidant, suggesting that this and related complexes have the potential to concurrently visualize and alleviate oxidative stress.
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