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A new chromone from the twig of Mallotus apelta
Tailiang Lu1, Shengping Deng, Chen Li
1a Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) , School of Environment and Resource of Guangxi Normal University , 15 Yu-Cai Road, Guilin 541004 , P.R. China.
Abstract:
A new chromone, 7-hydroxy-2-hydroxymethyl-8-methoxy-4-oxo-4H-chromene-6-carboxylic acid, named melachromone, along with 13 known compounds (2-14), including chromones, flavonoids, coumarins and phenylpropane derivatives, were isolated from the twig of Mallotus apelta. Their chemical structures were elucidated by using various spectroscopic methods. Anti-tumour evaluation of the compounds suggested that compound 1 exhibited medium cytotoxic activity against KB and HeLa Cells, with IC50 values of 9.50 and 9.23 μg mL(-1), respectively.
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