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[Research progress of negative costimulator B7-H4 in urologic tumors]

Yan Tao1, Mei Hong1

  • 1Institute of Urology, Second Hospital of Lanzhou University, Gansu Provincial Key Laboratory of Urological Diseases, Gansu Nephro-Urological Clinical Center, Lanzhou 730030, China.

Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences
|September 5, 2014
PubMed

Insights

B7-H4, an immune checkpoint, inhibits T cell responses and is linked to urologic tumor progression. Understanding its role offers new diagnostic and therapeutic strategies for these cancers.

Area of Science:

  • Immunology
  • Oncology

Context:

  • B7-H4 is a novel immune checkpoint protein.
  • It negatively regulates T cell responses.
  • Abnormal B7-H4 expression is observed in various human cancers.

Purpose:

  • To review the recent advancements in B7-H4 research concerning urologic tumors.
  • To highlight the association between B7-H4 expression and the progression/prognosis of urologic malignancies.

Summary:

  • B7-H4, a member of the B7 costimulation superfamily, suppresses T cell proliferation, activation, and cytokine production.
  • Its aberrant expression correlates with the progression and prognosis of urologic tumors.
  • This review consolidates current knowledge on B7-H4's role in urologic oncology.

Impact:

  • Elucidating B7-H4's function can lead to novel diagnostic biomarkers for urologic tumors.
  • Targeting B7-H4 may offer new avenues for effective immunotherapies in urologic cancer treatment.

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