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Paediatric HIV grows up: recent advances in perinatally acquired HIV

Alasdair Bamford1, Hermione Lyall2

  • 1Department of Paediatric Infectious Diseases and Immunology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Archives of Disease in Childhood
|September 5, 2014
PubMed

Insights

Paediatric HIV care in the UK and Ireland has seen success in preventing mother-to-child transmission. The focus is shifting towards long-term health for children living with HIV, addressing challenges of aging and lifelong treatment.

Area of Science:

  • Paediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Review of the current landscape of paediatric HIV in the UK and Ireland.
  • Highlights successes in preventing mother-to-child transmission of HIV.
  • Addresses the evolving epidemiology of HIV in children within the UK.

Purpose of the Study:

  • To provide an update on the status of paediatric HIV in the UK and Ireland.
  • To discuss the shift in treatment guidelines towards long-term health in adulthood.
  • To consider current and future challenges in managing paediatric HIV.

Main Methods:

  • This is a review article, synthesizing existing data and literature.
  • Focuses on summarizing epidemiological changes and treatment guideline evolution.
  • Considers challenges related to an aging cohort and transition to adult services.

Main Results:

  • Significant success has been achieved in preventing mother-to-child transmission.
  • The emphasis in treatment has shifted from short-term outcomes to lifelong health management.
  • Challenges include managing an aging cohort and the prospect of lifelong antiretroviral therapy.

Conclusions:

  • Despite decreasing numbers, lessons from the UK cohort are globally relevant.
  • Ensuring optimal health status in adult life is a key goal for paediatric HIV management.
  • Future considerations include ART-free survival and successful transition to adult care.

Keywords:
AdolescentAntiretroviral treatmentChildHIV

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