Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

9
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
9
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

31
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
31
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

25
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
25
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

519
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
519
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

481
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
481
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

649
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
649

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Intracranial atherosclerotic disease: epidemiology, imaging, treatment and prognosis, volume II.

Frontiers in neurology·2023
Same author

Editorial: Intracranial Atherosclerotic Disease: Epidemiology, Imaging, Treatment and Prognosis.

Frontiers in neurology·2021
Same author

Real-world stent retriever thrombectomy for acute ischemic stroke beyond 6 hours of onset: analysis of the NASA and TRACK registries.

Journal of neurointerventional surgery·2018
Same author

North American Solitaire Stent Retriever Acute Stroke registry: post-marketing revascularization and clinical outcome results.

Journal of neurointerventional surgery·2018
Same author

Clinical and Angiographic Outcomes with the Combined Local Aspiration and Retriever in the North American Solitaire Stent-Retriever Acute Stroke (NASA) Registry.

Interventional neurology·2018
Same author

First Pass Effect: A New Measure for Stroke Thrombectomy Devices.

Stroke·2018

Related Experiment Video

Updated: Apr 24, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

14.4K

Intra-arterial therapy for acute ischemic stroke.

Alex Abou-Chebl1

  • 1Department of Neurology, University of Louisville School of Medicine, Louisville, Ky., USA.

Interventional Neurology
|September 5, 2014
PubMed
Summary

Intra-arterial therapy (IAT) for acute ischemic stroke is improving with mechanical methods like embolectomy. However, further research is needed to confirm its safety and effectiveness compared to other treatments.

Keywords:
Acute ischemic strokeEmbolectomyIntra-arterial therapyIntravenous tissue plasminogen activatorMultimodal approaches

More Related Videos

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

9.9K
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

14.3K

Related Experiment Videos

Last Updated: Apr 24, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

14.4K
Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

9.9K
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

14.3K

Area of Science:

  • Neurology
  • Interventional Neuroradiology
  • Vascular Surgery

Background:

  • Intra-arterial therapy (IAT) for acute ischemic stroke is a rapidly evolving field.
  • Traditional intra-arterial fibrinolysis shows limited recanalization efficacy.
  • Mechanical approaches, including stenting and embolectomy, offer improved recanalization but haven't consistently translated to overwhelming clinical benefit.

Purpose of the Study:

  • To evaluate the evolving landscape of intra-arterial therapy (IAT) for acute ischemic stroke.
  • To identify potential reasons for suboptimal clinical outcomes despite improved reperfusion techniques.
  • To highlight the need for rigorous clinical trials to establish safety and efficacy.

Main Methods:

  • Review of current intra-arterial therapy (IAT) modalities for acute ischemic stroke.
  • Discussion of factors potentially limiting treatment success, including patient selection, technique, and complications.
  • Identification of knowledge gaps requiring further investigation through clinical trials.

Main Results:

  • Mechanical recanalization techniques demonstrate higher efficacy than traditional fibrinolysis.
  • Clinical benefits have not always matched reperfusion success, with reasons remaining unclear.
  • Intracerebral hemorrhage remains a complication, occurring in 2-11% of procedures.

Conclusions:

  • Large prospective and randomized clinical trials are essential to ascertain the safety and efficacy of various IAT approaches (pharmacological, embolectomy, stenting, multimodal).
  • Comparative studies, particularly between newer stent retrievers and intravenous tissue plasminogen activators for the 3- to 4.5-hour window, are warranted.