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Matrix metalloproteinase 9 is involved in airway inflammation in cough variant asthma

Hui-Ping Ma1, Wei Li2, Xiao-Min Liu3

  • 1Department of Respiratory Medicine, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China.

Experimental and Therapeutic Medicine
|September 5, 2014
PubMed

Insights

Matrix metalloproteinase 9 (MMP9) is elevated in cough variant asthma (CVA) airway inflammation. Treatment with inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) significantly reduced MMP9, IL-5, and eosinophils, suggesting MMP9 is a key biomarker.

Area of Science:

  • Pulmonology
  • Immunology
  • Biochemistry

Background:

  • Matrix metalloproteinase 9 (MMP9) is implicated in asthma and COPD pathogenesis.
  • The role of MMP9 in airway inflammation specific to cough variant asthma (CVA) is not well understood.

Purpose of the Study:

  • To investigate the levels of MMP9 and interleukin-5 (IL-5) in induced sputum of CVA patients.
  • To assess the impact of inhaled corticosteroid and long-acting β2-agonist (ICS/LABA) therapy on these markers.

Main Methods:

  • Quantification of MMP9, IL-5, and eosinophils (EOS) in induced sputum from CVA patients and healthy controls.
  • Comparison of marker levels before and after 6-9 months of ICS/LABA treatment.

Main Results:

  • CVA patients exhibited significantly higher levels of MMP9, IL-5, and EOS compared to controls.
  • ICS/LABA therapy led to a significant reduction in MMP9, IL-5, and EOS in CVA patients.

Conclusions:

  • MMP9 is elevated in the airway inflammation associated with CVA.
  • MMP9 may serve as a valuable biomarker for monitoring airway inflammation and treatment response in CVA.
Keywords:
cough variant asthmainflammationmatrix metalloproteinase 9

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