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HMOX1 gene promoter polymorphism is not associated with coronary artery disease in Koreans

Seong Woo Han1, Wonkeun Song2, Han-Sung Kim2

  • 1Department of Cardiology, Hallym University College of Medicine, Seoul, Korea.

Annals of Laboratory Medicine
|September 5, 2014
PubMed

Insights

Heme oxygenase-1 (HMOX1) gene polymorphisms are not linked to coronary artery disease (CAD) in Koreans. However, carriers of the short HMOX1 allele showed lower high-sensitivity C-reactive protein levels, indicating reduced cardiovascular risk.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Molecular Biology

Background:

  • Heme oxygenase-1 (HMOX1) gene polymorphisms influence gene transcription in response to oxidative stress.
  • Investigating the association between HMOX1 polymorphisms and coronary artery disease (CAD) is crucial for understanding disease mechanisms.

Purpose of the Study:

  • To screen for HMOX1 polymorphisms.
  • To investigate the association between HMOX1 polymorphisms and CAD in the Korean population.

Main Methods:

  • Study population included 110 CAD patients with obstructive lesions, 40 with minimal/no lesions, and 107 controls.
  • PCR analysis of the 5'-flanking region containing (GT)n repeats of the HMOX1 gene.
  • Follow-up coronary angiography in 39 CAD patients to assess restenosis.

Main Results:

  • HMOX1 (GT)n repeats showed a bimodal distribution, categorized into S25 (≤25 repeats) and L25 (>25 repeats) alleles.
  • No statistically significant differences in allele or genotype frequencies were observed among CAD and control groups.
  • S25 allele carriers had significantly lower high-sensitivity C-reactive protein (hsCRP) levels compared to non-carriers (P=0.034).

Conclusions:

  • HMOX1 genotypes were not associated with CAD in the Korean population.
  • Carriers of the short (S25) HMOX1 allele exhibited hsCRP levels indicative of a lower cardiovascular disease risk.
  • Further research may explore the protective role of the S25 allele in cardiovascular health.
Abstract

Keywords:
Coronary artery diseaseHMOX1 geneHeme oxygenase-1Polymorphism

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