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Current pipelines for neglected diseases.

Paolo di Procolo1, Claudio Jommi2

  • 1Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy.

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Summary
This summary is machine-generated.

This study analyzed clinical trials for Neglected Diseases (NDs), finding disease diffusion risk drives trial targets more than prevalence. Most trials focused on prevention and treatment, with research centers and public organizations as key sponsors.

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Area of Science:

  • * Medical Research & Public Health
  • * Infectious Diseases Epidemiology
  • * Global Health Policy

Background:

  • * Neglected Diseases (NDs) represent a significant global health burden, yet research and development pipelines remain under-scrutinized.
  • * Understanding investment trends and trial characteristics is crucial for optimizing resource allocation in ND research.
  • * Existing literature often lacks comprehensive, up-to-date analyses of ND clinical trial landscapes.

Purpose of the Study:

  • * To scrutinize clinical trial pipelines for Neglected Diseases (NDs) using freely accessible databases.
  • * To analyze disease-specific information, investment trends, trial locations, and patient recruitment status.
  • * To identify key drivers influencing clinical trial target selection and research objectives.

Main Methods:

  • * Comprehensive search of freely accessible, weekly updated clinical trials databases up to 2012.
  • * Integration of trial data with information on coordinator locations and patient recruitment status.
  • * Analysis of disease-specific rationales, yearly investment trends, and trial phases.

Main Results:

  • * 650 clinical studies identified; Leishmaniasis, Arbovirus infection, and Dengue lead in trial numbers.
  • * Disease diffusion risk appears to be the primary driver for clinical trial targeting.
  • * Most studies (57.6%) completed patient recruitment; prevention (49.3%) and treatment (43.2%) are primary objectives.

Conclusions:

  • * Research centers and public organizations are major sponsors of ND clinical trials.
  • * A significant portion of trial coordination occurs in less affluent countries, though OECD and BRICS nations are also involved.
  • * Findings enhance evidence on ND pipelines, suggesting future research on trial metrics' consistency with country characteristics.