Related Experiment Video
Updated: Jan 20, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Effect of diazepam on the frog neuromuscular junction
Abstract:
Diazepam (10(-5) M) had no effect on the compound action potential of frog sciatic nerve and its refractory period. At the neuromuscular junction, no changes were found in the amplitude and frequency of miniature endplate potentials in the presence of the drug. End-plate potential (e.p.p.) amplitude and early facilitation of the e.p.p. were unchanged. Diazepam had no effect on the amplitude of potentials evoked by ACh applied iontophoretically (0.1 Hz) at low frequencies in the chemosensitive region of the postjunctional membrane. Diazepam (10(-6) M) enhanced the progressive desensitization to ACh applied at a frequency of 1 Hz but did not affect recovery of sensitivity. A possible mechanism of action of diazepam at cholinergic synapses is discussed.
Related Concept Videos
Heart Failure V: Medical Management
Myocarditis III: Medical Management
Endocarditis III: Medical Management
06:59A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Inhaled Medications
Preparing and Administering Inhaled Medications
Inhaled medications are prescribed for conditions affecting the bronchi, which branch off of the trachea, and bronchioles, which are progressively smaller conducting airways spread throughout the lung tissue. These conditions can be classified as acute (i.e., temporary, with quick onset) or chronic (i.e., persistent and/or recurrent symptoms lasting months to years). Common acute conditions...