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Genetic polymorphisms and kidney transplant outcomes.
Sourabh Chand1, Amy Jayne McKnight, Richard Borrows
1aDepartment of Nephrology and Kidney Transplantation, Queen Elizabeth Hospital Birmingham bCentre for Translational Inflammation Research, University of Birmingham, Birmingham, UK cRegional Nephrology Unit, Belfast City Hospital, Belfast, Northern Ireland.
Current Opinion in Nephrology and Hypertension
|September 5, 2014
Summary
Genetic studies in renal transplantation are advancing rapidly, focusing on immunity and inflammation to improve patient outcomes. Future research will integrate genetics, environment, and donor factors for better long-term results.
Area of Science:
- Nephrology
- Immunogenetics
- Transplantation Science
Background:
- Gene polymorphism studies in renal transplantation are rapidly expanding.
- Research aims to enhance immediate and long-term outcomes for transplant recipients.
Purpose of the Study:
- To review recent evidence in genetic research for renal transplantation.
- To highlight potential future directions for genetic studies in this field.
Main Methods:
- Review of recent genetic research, including genome-wide association studies and candidate gene analyses.
- Analysis of meta-analyses and studies on copy number variation and donor genetics.
Main Results:
- Current studies focus on immunity, inflammation, and pharmacogenetics, often with conflicting surrogate outcomes.
- Recent advances include genome-wide association studies, multicenter analyses, meta-analyses, and increased interest in copy number variation and donor genetics.
Conclusions:
- These genetic studies provide a foundation for understanding disease pathways and identifying risk biomarkers in transplantation.
- Future research should emphasize donor-recipient interactions, gene-environment interactions, and adopt an integrated 'transplantomics' approach for long-term outcomes.
- Multinational collaborations are crucial for evaluating long-term outcomes in renal transplantation through comprehensive genetic analysis.
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