Molecular imaging in hereditary succinate dehydrogenase mutation-related paragangliomas
Maria Cristina Marzola1, Domenico Rubello
1From the Department of Nuclear Medicine and PET/CT Centre, S. Maria della Misericordia Hospital, Rovigo, Italy.
Abstract:
Multiple paraganglioma (PGL) syndromes related to succinate dehydrogenase (SDH) gene mutations are rare hereditary conditions. These present with heterogeneous clinical signs and symptoms and in many cases are difficult to classify. We summarize the pathophysiological, clinical, laboratory, and morphological and functional imaging characteristics of SDH gene mutation PGLs, emphasizing F-FDG and F-DOPA PET/CT. We correlate clinical and genetic features of SDH-related PGLs with specific PET radiopharmaceuticals, with the aim to obtain an "individualized" diagnostic approach.
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