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[Thyroid dysfunction in adults infected by human immunodeficiency virus].

Erika Abelleira1, Graciela A De Cross, Fabián Pitoia

  • 1División Endocrinología, Hospital de Clínicas, Universidad de Buenos Aires, Argentina.

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Summary

HIV patients show increased thyroid dysfunction, including Graves' disease and hypothyroidism. Highly active antiretroviral therapy may contribute to these thyroid issues, necessitating routine monitoring.

Keywords:
HIVantiretroviral therapyhyperthyroidismhypothyroidismthyroid

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Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Pharmacology

Context:

  • Human immunodeficiency virus (HIV) infection is associated with a higher prevalence of thyroid dysfunction compared to the general population.
  • Common manifestations include euthyroid sick syndrome, Graves' disease, and subclinical hypothyroidism.
  • The use of highly active antiretroviral therapy (HAART) has been linked to an increased incidence of thyroid dysfunction in HIV patients.

Purpose:

  • To explore the relationship between HIV infection, HAART, and thyroid dysfunction.
  • To identify specific antiretroviral drugs associated with thyroid abnormalities.
  • To highlight the need for routine thyroid function assessment in HIV-infected individuals.

Summary:

  • HIV patients exhibit a greater prevalence of thyroid dysfunction.
  • Graves' disease can arise from immune reconstitution syndrome post-HAART.
  • Certain antiretroviral drugs, like stavudine and efavirenz, are implicated in hypothyroidism development.

Impact:

  • Findings underscore the importance of monitoring thyroid function in HIV patients undergoing HAART.
  • Highlights potential drug-induced thyroid toxicity associated with specific antiretroviral agents.
  • Suggests a need for further research to confirm and expand upon these associations.