Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetic Foot Ulcer

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...

Peripheral Artery Disease IV: Nursing Management

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...

Peripheral Artery Disease V: Postoperative Nursing Management

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Healing II: Complications

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Assessment of the Cardiovascular System III: Palpation

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Time-Synchronized Multi-Sensor drone dataset acquired from multiple radars and RF receiver.

Scientific data·2026

Same author

Correlation Between Small Dense Low-Density Lipoprotein and Tissue Perfusion in Diabetic Foot.

Journal of Korean medical science·2026

Same author

Developing a framework for infection control education in nursing homes: Applying the mixed-methods Delphi technique.

Journal of Korean gerontological nursing·2026

Same author

Longitudinal Assessment of Facial Scars After Acellular Dermal Matrix Grafting Post-Skin Cancer Resection: Focus on Color and Contraction.

Plastic and reconstructive surgery·2025

Same author

Biomimetic Full-Thickness Artificial Skin Using Stromal Vascular Fraction Cells and Autologous Keratinocytes in a Single Scaffold for Wound Healing.

Bioengineering (Basel, Switzerland)·2025

Same author

Tri-Layered Full-Thickness Artificial Skin Incorporating Adipose-Derived Stromal Vascular Fraction Cells, Keratinocytes, and a Basement Membrane.

Bioengineering (Basel, Switzerland)·2025

Search research articles

Related Experiment Video

Updated: Apr 24, 2026

A Simplified Technique for Producing an Ischemic Wound Model

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

Can macrocirculation changes predict nonhealing diabetic foot ulcers?

Ye-Na Lee¹, Hyon-Surk Kim, Jeong-A Kang

¹Ye-Na Lee, RN, CWCN, Diabetic Wound Center, Korea University Guro Hospital, Seoul, Korea. Hyon-Surk Kim, MD, Clinical Instructor, Department of Plastic Surgery, University Anam Hospital, Seoul, Korea. Jeong-A Kang, RN, Diabetic Wound Center, Korea University Guro Hospital, Seoul, Korea. Seung-Kyu Han, MD, PhD, Professor, Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea.

Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society

|September 5, 2014

Summary

Macrocirculation assessment via CT angiography and Doppler ultrasound does not reliably predict tissue oxygenation in diabetic foot ulcer patients. Transcutaneous partial oxygen tension (TcpO2) remains crucial for treatment decisions.

More Related Videos

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Related Experiment Videos

Last Updated: Apr 24, 2026

A Simplified Technique for Producing an Ischemic Wound Model

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Area of Science:

Vascular Medicine
Diabetology
Wound Healing Research

Background:

Tissue oxygenation is vital for wound healing, with transcutaneous partial oxygen tension (TcpO2) as the gold standard.
Diabetic foot ulcers often involve macrocirculatory issues impacting tissue oxygenation.

Purpose of the Study:

To investigate the correlation between macrocirculation status and TcpO2 in diabetic patients.
To assess if non-invasive vascular imaging can substitute TcpO2 measurements for treatment guidance.

Main Methods:

Ninety-eight diabetic foot ulcer patients were evaluated.
Macrocirculation assessed using computed tomographic angiography and Doppler ultrasound.
Tissue oxygenation measured via TcpO2; macrocirculation scores analyzed against TcpO2.

Main Results:

No significant linear trend was found between macrocirculation status and TcpO2.
Bivariate analyses (Fisher exact, Mantel-Haenszel, McNemar-Bowker tests) showed no significant relationship.
Neither CT angiography nor Doppler ultrasound reliably correlated with TcpO2 levels.

Conclusions:

Computed tomographic angiography and Doppler ultrasound are insufficient to replace TcpO2 measurements.
Accurate assessment of tissue oxygenation via TcpO2 is essential for optimal treatment planning in diabetic patients.