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Primary lung cancer coexisting with active pulmonary tuberculosis
1Chest Diseases Clinic, Izmir Dr Suat Seren Chest Diseases and Surgery Training and Research Hospital, Izmir, Turkey.
Summary
Lung cancer and active pulmonary tuberculosis (TB) often coexist, predominantly in males as squamous cell carcinoma. Concomitant active TB did not negatively impact lung cancer patient survival.
Area of Science:
- Oncology
- Pulmonology
- Infectious Diseases
Background:
- Comorbidity of lung cancer and active pulmonary tuberculosis (TB) presents diagnostic and therapeutic challenges.
- Understanding the clinical profile and survival of patients with both conditions is crucial.
Purpose of the Study:
- To elucidate the clinical and survival characteristics of patients diagnosed with both lung cancer and active pulmonary TB.
Main Methods:
- A retrospective evaluation of 3350 TB patients admitted between 2008 and 2013.
- Analysis of demographic, clinical, histological, and survival data for patients with coexisting lung cancer and TB.
Main Results:
- Lung cancer and active pulmonary TB coexisted in 38 (1.1%) male patients.
- Squamous cell carcinoma was the predominant histology (60.7%). Most patients were diagnosed at advanced stages (III or IV).
- Median overall survival was 13.4 months; one-year survival rates varied by stage, from 40% (Stage IV) to 100% (Stage I).
Conclusions:
- Lung cancer with active pulmonary TB commonly presents as squamous cell carcinoma in males.
- The presence of active TB did not alter the overall survival of lung cancer patients in this cohort.
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