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RSV infection among children born moderately preterm in a community-based cohort

Rolof G P Gijtenbeek1, Jorien M Kerstjens, Sijmen A Reijneveld

  • 1Department of Paediatrics, Neonatology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, rolof.gijtenbeek@znb.nl.

European Journal of Pediatrics
|September 6, 2014
PubMed

Insights

Hospitalization rates for respiratory syncytial virus (RSV) are higher in moderately preterm (MP) infants compared to full-term (FT) infants. Risk factors for MP hospitalization include shorter gestational age and passive smoking exposure.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Respiratory syncytial virus (RSV) is a common respiratory pathogen in infants.
  • Preterm birth is associated with increased risk of severe respiratory infections.
  • Understanding RSV hospitalization rates across different gestational ages is crucial for public health interventions.

Purpose of the Study:

  • To compare RSV hospitalization rates and disease severity in moderately preterm (MP), early preterm (EP), and full-term (FT) infants.
  • To identify risk factors for RSV hospitalization specifically among MP infants.

Main Methods:

  • A community-based cohort study involving children aged 43-49 months.
  • Data collection via parental questionnaires and medical records.
  • Comparison of RSV hospitalization rates and disease severity across three groups: MP (GA 32-36 weeks), EP (GA <32 weeks), and FT (GA 38-42 weeks).

Main Results:

  • RSV hospitalization rates were higher in MP infants (3.9%) compared to FT infants (1.2%).
  • RSV hospitalization rates were similar between MP (3.9%) and EP (3.2%) infants.
  • Disease severity was comparable across all groups.
  • For MP infants, younger age, lower birth weight, shorter gestational age, and passive smoking exposure were identified as risk factors for RSV hospitalization.

Conclusions:

  • Moderately preterm infants experience higher rates of RSV hospitalization than full-term infants.
  • Gestational age and passive smoking are significant risk factors for RSV hospitalization in moderately preterm infants.
  • No significant difference in disease severity was observed among the studied groups.
Abstract

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