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Genetics of obstructive sleep apnea/hypopnea syndrome
Dongmei Zhang1, Yi Xiao2, Jinmei Luo2
1Department of Internal Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Objective:
To have a better understanding of genetic contributions to the development of obstructive sleep apnea hypopnea syndrome (OSAHS) by reviewing studies on its genetic basis.
Data Sources:
A comprehensive search of the PubMed literature without restriction on the publication date was carried out using terms "obstructive sleep apnea" and "candidate genes" or "genetics".
Study Selection:
Articles were selected if they were an original research paper or meta analysis of the genetic factors of OSAHS.
Results:
Four intermediate phenotypes were described and several candidate genes that may determine the expression and severity of OSAHS were reviewed.
Conclusion:
Multiple gene-gene interactions occurring in genes that affect obesity, craniofacial structure, ventilator control and asleep-awake pattern may influence the expression of OSAHS in a suitable environment.
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