Related Experiment Video
Updated: Apr 24, 2026

Author Spotlight: Hypothalamic Neural Mechanism Insights
Published on: August 4, 2023
Molecular mechanisms involved in the control of neurohypophyseal hormones secretion
M Iovino, E Guastamacchia, V A Giagulli
1Interdisciplinary Department of Medicine-Endocrinology and Metabolic Diseases. University of Bari "Aldo Moro", Bari, Italy. micheleiovino06@libero.it.
Abstract:
The regulation of neurohypophyseal peptides secretion reflects the convergence of a large number of afferent neural pathways on vasopressinergic and oxytocinergic neurons of supraoptic (SON) and paraventricular nuclei (PVN). In addition to afferent input, vasopressin and oxytocin can also exert an autocrine regulation of neuronal activity. In fact, magnocellular neurons (MCNs) of SON and PVN are able to secrete these hormones not only at the endings of their terminal axons, but also from their dendrites and this local release, by activating a range of ion gated, ion channel and G protein coupled receptors, participate in pre- and post-synaptic modulation of neural activity of MCNs. In this review we analyzed the molecular mechanisms involved in the control of neurohypophyseal hormones secretion and related possible pharmacological targets.
More Related Videos
Related Concept Videos
Regulation of Hormone Secretion
Humoral...
Hormones of the Pituitary Gland
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
Major Hormones and Their Functions
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Regulation of Food Intake
Feedback Loops
The Pituitary Gland

