Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

2.6K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.6K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

10.7K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
10.7K
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

1.3K
In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
1.3K
Coagulation01:09

Coagulation

8.3K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
8.3K
Coagulation01:06

Coagulation

1.5K
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.5K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

It's time to improve antithrombotic therapy! A global perspective for antithrombotic stewardship.

European journal of internal medicine·2026
Same author

Hamostaseologie·2019
Same author

[Modern treatment of deep vein thrombosis and pulmonary embolism].

Der Internist·2019
Same author

Low incidence of heparin-induced skin lesions in orthopedic surgery patients with low-molecular-weight heparins.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2018
Same author

A multicenter study to assess the reproducibility of antiphospholipid antibody results produced by an automated system.

Journal of thrombosis and haemostasis : JTH·2016
Same author

Screening for lupus anticoagulants in patients treated with vitamin K antagonists.

International journal of laboratory hematology·2015

Related Experiment Video

Updated: Apr 24, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
06:59

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

164

[Incidental finding of pathological coagulation parameters].

B Luxembourg1, E Lindhoff-Last

  • 1Institut für Transfusionsmedizin und Immunhämatologie, DRK-Blutspendedienst Baden-Württemberg - Hessen, Universitätsklinik Frankfurt, Sandhofstr. 1, 60528, Frankfurt a. M., Deutschland, b.luxembourg@blutspende.de.

Der Internist
|September 6, 2014
PubMed
Summary
This summary is machine-generated.

Pathological coagulation tests can indicate serious bleeding or clotting disorders, or be due to lab errors. This guide helps interpret abnormal results, considering anticoagulants and D-dimer levels for accurate diagnosis.

More Related Videos

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.2K
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

16.3K

Related Experiment Videos

Last Updated: Apr 24, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
06:59

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

164
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.2K
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

16.3K

Area of Science:

  • Clinical Pathology
  • Hematology
  • Diagnostic Medicine

Context:

  • Coagulation parameters are crucial for diagnosing bleeding and clotting disorders.
  • Abnormal results may stem from various causes, including preanalytical errors, in vitro phenomena, or underlying diseases.
  • Modern anticoagulants significantly influence coagulation test results.

Purpose:

  • To provide an overview of potential pitfalls in coagulation diagnostics.
  • To list differential diagnoses for pathological coagulation parameters.
  • To describe diagnostic steps for clarifying abnormal coagulation test results.

Summary:

  • This article reviews common coagulation tests like platelet count, prothrombin time, activated partial thromboplastin time (aPTT), and fibrinogen.
  • It discusses the impact of various anticoagulants (heparin, vitamin K antagonists, direct oral anticoagulants) on these parameters.
  • It also addresses elevated D-dimer levels, emphasizing their limited specificity and utility in ruling out venous thromboembolism when normal.

Impact:

  • Aids clinicians in accurately interpreting abnormal coagulation test results.
  • Improves diagnostic accuracy by differentiating true pathological findings from analytical interferences.
  • Enhances patient management by guiding appropriate further investigations and treatment decisions.