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Updated: Apr 24, 2026

Extraction of Plant-based Capsules for Microencapsulation Applications
Published on: November 9, 2016
Comparison of directly compressed vitamin B12 tablets prepared from micronized rotary-spun microfibers and cast films
István Sebe1, Zsolt Bodai, Zsuzsanna Eke
1a University Pharmacy Department of Pharmacy Administration , Semmelweis University , Budapest , Hungary .
Abstract:
Fiber-based dosage forms are potential alternatives of conventional dosage forms from the point of the improved extent and rate of drug dissolution. Rotary-spun polymer fibers and cast films were prepared and micronized in order to direct compress after homogenization with tabletting excipients. Particle size distribution of powder mixtures of micronized fibers and films homogenized with tabletting excipients were determined by laser scattering particle size distribution analyzer. Powder rheological behavior of the mixtures containing micronized fibers and cast films was also compared. Positron annihilation lifetime spectroscopy was applied for the microstructural characterization of micronized fibers and films. The water-soluble vitamin B12 release from the compressed tablets was determined. It was confirmed that the rotary spinning method resulted in homogeneous supramolecularly ordered powder mixture, which was successfully compressed after homogenization with conventional tabletting excipients. The obtained directly compressed tablets showed uniform drug release of low variations. The results highlight the novel application of micronized rotary-spun fibers as intermediate for further processing reserving the original favorable powder characteristics of fibrous systems.
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