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Cerebrovascular markers in lowered cognitive function

Maria Mataró1, Juan José Soriano-Raya2, Jorge López-Olóriz1

  • 1Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Barcelona, Spain.

Journal of Alzheimer'S Disease : JAD
|September 6, 2014
PubMed

Insights

Cerebrovascular disease markers are key for detecting cognitive decline risk. This review covers neuroimaging, sonographic, and blood markers for early identification in subclinical individuals.

Area of Science:

  • Neurology
  • Gerontology
  • Medical Diagnostics

Background:

  • Cerebrovascular disease (CVD) significantly contributes to age-related cognitive decline and dementia.
  • Early identification of individuals at high risk for cognitive decline is crucial.
  • In vivo markers aid in understanding CVD pathology and disease progression.

Purpose of the Study:

  • To review common cerebrovascular markers associated with cognitive decline in subclinical individuals.
  • To highlight the importance of these markers for early detection and intervention.

Main Methods:

  • Literature review of common cerebrovascular markers.
  • Focus on markers detectable in subclinical individuals.
  • Categorization of markers into neuroimaging, sonographic, and blood-based.

Main Results:

  • Identified key neuroimaging markers (e.g., white matter hyperintensities, lacunes).
  • Highlighted sonographic markers (e.g., carotid intima-media thickness).
  • Discussed relevant blood markers (e.g., inflammatory markers, endothelial dysfunction markers).

Conclusions:

  • Cerebrovascular markers are vital for early detection of cognitive decline risk.
  • Neuroimaging, sonographic, and blood markers offer valuable insights.
  • These markers can guide preventive strategies and patient monitoring.

Keywords:
BiomarkersMRI markersblood markerscerebrovascular diseasecognitive impairmentsonographic markers

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