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Related Concept Videos

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Related Experiment Video

Updated: Apr 24, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
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Crystalglobulin-induced nephropathy.

Vinay Gupta1, Mireille El Ters2, Kianoush Kashani3

  • 1Divisions of Hematology.

Journal of the American Society of Nephrology : JASN
|September 6, 2014
PubMed
Summary
This summary is machine-generated.

Crystalline nephropathy involves crystal deposition in the kidneys, causing damage. This report details crystalglobulinemia, a rare form linked to multiple myeloma, and its impact on kidney function.

Keywords:
ARFkidney biopsymyeloma

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Area of Science:

  • Nephrology
  • Renal Pathology
  • Hematology

Background:

  • Crystalline nephropathy encompasses diverse renal conditions caused by crystal deposition.
  • Common forms include nephrocalcinosis and oxalate nephropathy.
  • Less frequent causes involve urate, cystinosis, dihydroxyadeninuria, and drug-induced crystal nephropathies.

Observation:

  • Monoclonal proteins can precipitate as crystals within renal tissues, leading to damage.
  • Conditions like light chain proximal tubulopathy and crystal-storing histiocytosis are associated with monoclonal protein crystal deposition.
  • Crystalglobulinemia, a rare complication of multiple myeloma, involves monoclonal protein crystallization in vasculature, causing injury and occlusion.

Findings:

  • This report presents a case of crystalglobulin-induced nephropathy.
  • It explores the underlying pathophysiology of this rare condition.
  • The discussion includes differential diagnoses for paraprotein-induced crystalline nephropathy.

Implications:

  • Understanding crystalglobulinemia is crucial for diagnosing and managing rare paraprotein-induced kidney diseases.
  • This case highlights the systemic vascular effects of monoclonal protein crystallization.
  • Further research into crystalglobulinemia can improve patient outcomes in multiple myeloma.