High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved
Siddhartha S Angadi1, Farouk Mookadam2, Chong D Lee3
1School of Nutrition and Health Promotion, Arizona State University, Phoenix, Arizona; Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, Arizona; and sangadi@asu.edu.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|September 6, 2014
Summary
High-intensity interval training (HIIT) significantly improved peak oxygen uptake and diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF) patients. This exercise intervention shows promise for early adaptations in HFpEF management.
Area of Science:
- Cardiology
- Exercise Physiology
- Rehabilitation
Background:
- Heart failure with preserved ejection fraction (HFpEF) contributes significantly to patient morbidity and mortality.
- Exercise training is a recognized adjunctive therapy for heart failure, but the specific benefits of high-intensity interval training (HIIT) in HFpEF remain unclear.
Purpose of the Study:
- To compare the effects of HIIT versus moderate-intensity aerobic continuous training (MI-ACT) on cardiorespiratory fitness, left ventricular diastolic function, and endothelial function in patients with HFpEF.
Main Methods:
- Nineteen HFpEF patients were randomized to either HIIT or MI-ACT for 4 weeks, training 3 days per week.
- Assessments included peak oxygen uptake (V̇o₂peak) via treadmill testing, left ventricular diastolic dysfunction via echocardiography, and endothelial function via brachial artery flow-mediated dilation (FMD).
Main Results:
- HIIT significantly improved V̇o₂peak and reduced the grade of left ventricular diastolic dysfunction.
- No significant changes in V̇o₂peak, diastolic dysfunction, or FMD were observed in the MI-ACT group.
- A trend towards reduced left atrial volume index was noted with HIIT compared to MI-ACT.
Conclusions:
- Four weeks of HIIT effectively improved cardiorespiratory fitness and diastolic function in HFpEF patients.
- HIIT appears to offer a more potent stimulus for early exercise training adaptations in HFpEF compared to MI-ACT.
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