Related Experiment Video
Updated: Apr 24, 2026

08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
18.0K
Management of melanoma
Pippa Corrie1, Mirela Hategan2, Kate Fife2
1Cambridge Cancer Centre, Cambridge University Hospitals NHS Foundation Trust (Addenbrooke's Hospital), Cambridge CB2 0QQ, UK pippa.corrie@addenbrookes.nhs.uk.
British Medical Bulletin
|September 6, 2014
Summary
Early diagnosis and integrated management are crucial for melanoma patients, especially with rising global incidence. Advances in systemic therapies like targeted agents and immunotherapies offer survival gains, necessitating proactive multidisciplinary care.
Area of Science:
- Oncology
- Dermatology
- Cancer Biology
Background:
- Melanoma is a curable cancer, but 20% of patients develop advanced disease.
- Rising global incidence necessitates improved management strategies.
Purpose of the Study:
- To review current understanding and management of melanoma.
- To highlight the need for integrated, multidisciplinary approaches.
Main Methods:
- Literature review of PubMed references on melanoma research and treatment.
Main Results:
- Melanoma incidence is rapidly increasing worldwide.
- Effective treatments include surgery, molecular targeted therapies, and immunotherapies.
- Early diagnosis and multidisciplinary interventions are essential.
Conclusions:
- Molecular factors increasingly guide melanoma treatment decisions.
- Screening, surveillance, and patient education are vital for improved outcomes.
Related Concept Videos
Skin Cancer
5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
Tumor Immunotherapy
2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
The Tumor Microenvironment
6.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.3K

