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Updated: Apr 24, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Management of melanoma
Pippa Corrie1, Mirela Hategan2, Kate Fife2
1Cambridge Cancer Centre, Cambridge University Hospitals NHS Foundation Trust (Addenbrooke's Hospital), Cambridge CB2 0QQ, UK pippa.corrie@addenbrookes.nhs.uk.
Background:
Melanoma is a potentially curable cancer, but around 20% of patients will develop disease which is beyond surgical clearance. Rising incidence alongside breakthroughs in understanding the molecular biology of this disease identifying systemic therapies offering survival gains now demand a more proactive, integrated approach to melanoma management.
Sources Of Data:
PubMed references relating to aspects of melanoma research and treatment.
Areas Of Agreement:
Rapidly rising incidence throughout the world. Effective surgery as well as new molecular targeted systemic biological agents and immunotherapies necessitating early diagnosis and multidisciplinary therapeutic interventions.
Areas Of Controversy:
Role of screening and prevention. Benefit of interventions for locoregional melanoma, including role of sentinel lymph node biopsy. Integration and sequencing of treatments for unresectable melanoma.
Growing Points:
Molecular determinants of melanoma influencing disease outcome and treatment decisions.
Areas Timely For Developing Research:
Education and training of patient and healthcare professionals. Role of screening, surveillance and follow-up strategies. Biology of melanoma guiding treatment decisions.
Insights
Early diagnosis and integrated management are crucial for melanoma patients, especially with rising global incidence. Advances in systemic therapies like targeted agents and immunotherapies offer survival gains, necessitating proactive multidisciplinary care.
Area of Science:
- Oncology
- Dermatology
- Cancer Biology
Background:
- Melanoma is a curable cancer, but 20% of patients develop advanced disease.
- Rising global incidence necessitates improved management strategies.
Purpose of the Study:
- To review current understanding and management of melanoma.
- To highlight the need for integrated, multidisciplinary approaches.
Main Methods:
- Literature review of PubMed references on melanoma research and treatment.
Main Results:
- Melanoma incidence is rapidly increasing worldwide.
- Effective treatments include surgery, molecular targeted therapies, and immunotherapies.
- Early diagnosis and multidisciplinary interventions are essential.
Conclusions:
- Molecular factors increasingly guide melanoma treatment decisions.
- Screening, surveillance, and patient education are vital for improved outcomes.
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