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Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
Thittamaranahalli Muguregowda Honnegowda1, Pramod Kumar1, Padmanabha Udupa2
1Department of Plastic Surgery and Burns, Kasturba Medical College, Manipal, Karnataka, India.
Background:
Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue.
Materials And Method:
A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (n = 17) and conventional dressing group (n = 17).
Results:
Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (P = 0.026), total protein (P = 0.004), GPx level (P = 0.030) and GST level (P = 0.045).
Conclusion:
Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.
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