Related Experiment Video
Updated: Apr 24, 2026

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies
Published on: November 19, 2020
Entropy as an indicator of cerebral perfusion in patients with increased intracranial pressure
James Khan1, Ramamani Mariappan1, Lashmi Venkatraghavan1
1Department of Anesthesia and Pain, Toronto Western Hospital, University Health Network, University of Toronto, Toronto ON, Canada.
Abstract:
Changes in electroencephalogram (EEG) patterns correlate well with changes in cerebral perfusion pressure (CPP) and hence entropy and bispectral index values may also correlate with CPP. To highlight the potential application of entropy, an EEG-based anesthetic depth monitor, on indicating cerebral perfusion in patients with increased intracranial pressure (ICP), we report two cases of emergency neurosurgical procedure in patients with raised ICP where anesthesia was titrated to entropy values and the entropy values suddenly increased after cranial decompression, reflecting the increase in CPP. Maintaining systemic blood pressure in order to maintain the CPP is the anesthetic goal while managing patients with raised ICP. EEG-based anesthetic depth monitors may hold valuable information on guiding anesthetic management in patients with decreased CPP for better neurological outcome.
Related Concept Videos
Increased Intracranial Pressure ll: Pathophysiology
Increased Intracranial Pressure l: Introduction
Cerebral Edema ll: Pathophysiology
Cerebral Edema l: Introduction
Cytotoxic Edema: Pathophysiology
Ischemic Stroke ll: Pathophysiology

