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Bifidobacterium bifidum as an example of a specialized human gut commensal

Francesca Turroni1, Sabrina Duranti2, Francesca Bottacini1

  • 1Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland Cork, Ireland.

Frontiers in Microbiology
|September 6, 2014
PubMed

Insights

Bifidobacterium bifidum is a key infant gut bacterium. This review covers its genetic adaptations, like epithelial adhesion and nutrient use, for thriving in the infant gut environment.

Area of Science:

  • Microbiology
  • Human Gut Microbiota
  • Bacterial Genetics

Background:

  • Bifidobacteria are dominant members of the human gut microbiota, especially in infants.
  • Bifidobacterium bifidum is a significant component of the infant gut bacterial population.
  • B. bifidum possesses unique traits for interacting with the host environment.

Purpose of the Study:

  • To review current knowledge on the genetic characteristics of Bifidobacterium bifidum.
  • To explore the adaptations of B. bifidum relevant to the human infant gut.
  • To highlight features enabling B. bifidum's colonization and persistence.

Main Methods:

  • Literature review of existing studies on Bifidobacterium bifidum.
  • Analysis of genetic features related to bacterial physiology and adaptation.
  • Synthesis of information on host-microbe interactions within the infant gut.

Main Results:

  • B. bifidum exhibits specialized mechanisms for adhering to intestinal epithelial cells.
  • B. bifidum possesses genetic capabilities for utilizing host-derived glycans as nutrients.
  • These features contribute to the dominance and success of B. bifidum in infants.

Conclusions:

  • Genetic features significantly influence B. bifidum's adaptation to the infant gut.
  • Understanding these adaptations is crucial for comprehending infant gut microbiome development.
  • B. bifidum's specialized traits underscore its importance in early life.

Keywords:
Bifidobacterium bifidumbifidobacteriagenomicsmicrobiotaprobiotics

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