Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

53
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
53
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
Bridge rectifier01:24

Bridge rectifier

2.1K
The bridge rectifier is essential in electronics for efficiently converting alternating current (AC) to direct current (DC). Comprised of four diodes configured in a bridge layout, this rectifier effectively processes both the positive and negative halves of the AC waveform, making it superior to half-wave and full-wave center-tapped rectifiers in terms of voltage regulation and output stability.
Operationally, the bridge rectifier allows current flow through two of its diodes during each...
2.1K
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

16
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
16

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temperature-dependent functional inversion of Ca<sub>v</sub>3.2 channels during repetitive activity.

Molecular brain·2026
Same author

Pathophysiology of homocysteine: insights into ion channel dysfunction.

Pflugers Archiv : European journal of physiology·2026
Same author

Limited role of light reflection rheography in detecting postthrombotic syndrome: Results of a pilot study.

Vascular medicine (London, England)·2026
Same author

[Prevention and prophylaxis in angiology].

Innere Medizin (Heidelberg, Germany)·2026
Same author

Low-dose versus high-dose drug-coated balloons for femoropopliteal lesions: 5-year results from the prospective, randomised COMPARE trial.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2026
Same author

[Open Thoracoabdominal Aortic Replacement for Midaortic Syndrome and COL3A1 Variant].

Zentralblatt fur Chirurgie·2026

Related Experiment Video

Updated: Apr 24, 2026

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

765

Rectifying rectifier channels in Huntington disease.

Juliane Proft1, Norbert Weiss1

  • 1Institute of Organic Chemistry and Biochemistry; Academy of Sciences of the Czech Republic; Prague, Czech Republic.

Communicative & Integrative Biology
|September 6, 2014
PubMed
Summary

Glial cells, particularly astrocytes, are increasingly recognized as crucial in neurodegenerative diseases. Astrocytic potassium channels are a key factor in Huntington disease pathogenesis.

Keywords:
HTTHuntingtinHuntington diseaseKir4.1NMDA receptorchannelexcitabilityglutamateneuronpotassium

More Related Videos

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

5.6K
Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
07:43

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons

Published on: January 7, 2019

6.4K

Related Experiment Videos

Last Updated: Apr 24, 2026

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

765
Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

5.6K
Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
07:43

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons

Published on: January 7, 2019

6.4K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Neurodegenerative Disorders

Background:

  • Decades of research have focused on neuronal abnormalities in neurodegenerative diseases like Huntington, Alzheimer, and Parkinson diseases.
  • Emerging evidence highlights the significant role of glial cells, especially astrocytes, in these conditions.

Purpose of the Study:

  • To investigate the role of astrocytes in neurodegenerative disorders.
  • To identify key molecular mechanisms, such as astrocytic potassium channels, involved in disease pathogenesis.

Main Methods:

  • Review of current literature on glial cell function in neurodegeneration.
  • Analysis of evidence implicating astrocytic potassium channels in Huntington disease.

Main Results:

  • Astrocytes are emerging as critical players alongside neurons in neurodegenerative diseases.
  • Astrocytic potassium channels are identified as a likely key factor in the pathogenesis of Huntington disease.

Conclusions:

  • The role of astrocytes in neurodegenerative disorders warrants further investigation.
  • Targeting astrocytic potassium channels may offer a novel therapeutic strategy for Huntington disease.