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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
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Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features...
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Updated: Apr 24, 2026

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
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Osteonecrosis Secondary to Paget's Disease: Radiologic and Pathologic Features.

Naveen Polisetti1, Mahesh Neerupakam2, Venkata Sarath Prathi3

  • 1Department of Oral and Maxillafacial Surgery, KLR'S Lenora Institute of Dental Sciences, Rajanagaram, Rajahmundry, India.

Journal of Clinical Imaging Science
|September 6, 2014
PubMed
Summary
This summary is machine-generated.

Paget

Keywords:
Bone diseasebone metabolism paget's diseaseosteitis deformansosteonecrosis

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Area of Science:

  • Orthopedics and Bone Metabolism

Background:

  • Paget's disease (PD) is a chronic bone disorder with uncertain etiology.
  • It involves abnormal bone metabolism, affecting single (monostotic) or multiple (polyostotic) bones.

Purpose of the Study:

  • To report a rare case of Paget's disease presenting as osteonecrosis of the maxilla.
  • To highlight the rarity of non-drug induced osteonecrosis in Paget's disease.

Main Methods:

  • Case report of a 70-year-old male patient.
  • Initial diagnosis of osteonecrosis of the maxilla.

Main Results:

  • Paget's disease was identified in the patient.
  • The presentation mimicked non-drug induced osteonecrosis, a rare occurrence in Paget's disease.

Conclusions:

  • This case underscores the diverse and sometimes atypical presentations of Paget's disease.
  • Emphasizes the importance of considering Paget's disease in cases of unexplained osteonecrosis, particularly of the maxilla.