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Updated: Apr 24, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

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Herpes Zoster Induced Osteomyelitis in the Immunocompromised Patients: A 10-year Multicenter Study

Reza Tabrizi1, Ali Dehghani Nazhvani2, Amir Vahedi3

  • 1Dept. of Craniomaxillofacial Surgery, School of Dentistry, Shiraz University of Medical Science, Shiraz, Iran.

Journal of Dentistry (Shiraz, Iran)
|September 6, 2014
PubMed
Abstract

Insights

Herpes zoster infection can cause rare mandibular osteomyelitis in immunocompromised patients. This study found a higher frequency than previously reported, with polymerase chain reaction (PCR) tests aiding diagnosis.

Area of Science:

  • Oral surgery
  • Infectious diseases
  • Pathology

Background:

  • Alveolar bone necrosis from Herpes zoster (HZ) infection is a rare form of osteomyelitis.
  • Existing literature contains limited case reports on this condition.

Purpose of the Study:

  • To evaluate mandibular osteomyelitis caused by HZ infection.
  • Focus on immunocompromised patients with confirmed osteomyelitis and HZ infection.

Main Methods:

  • Cross-sectional study of 30 patients.
  • Patient groups included edentulous and dentate individuals.
  • Conventional polymerase chain reaction (PCR) used to detect varicella zoster virus in specimens.

Main Results:

  • 16 patients on dialysis, 9 on chemotherapy, 5 post-transplant.
  • Histopathology showed nonspecific bone necrosis.
  • PCR was positive in 21 out of 30 cases.

Conclusions:

  • The frequency of HZ-induced osteomyelitis may be underestimated in current literature.
  • Histopathological findings can be nonspecific.
  • PCR testing was not positive in all cases of HZ-induced osteomyelitis.
Keywords:
Herpes zosterMandibleOsteomyelitisZona

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