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Area of Science:

  • Biomedical Research
  • Cardiovascular Epidemiology
  • Inflammation Biomarkers

Background:

  • C-reactive protein (CRP) is a known inflammation marker.
  • Previous studies suggest CRP is linked to stroke risk, but data in Asian populations and for specific stroke subtypes are limited.

Purpose of the Study:

  • To investigate the association between high-sensitivity CRP (hs-CRP) levels and the risk of all stroke and its subtypes in a Chinese adult population.
  • To examine stroke subtypes including ischemic stroke (IS), intracranial hemorrhage (ICH), and subarachnoid hemorrhage (SAH).

Main Methods:

  • A cohort of 90,517 Chinese adults without prior stroke or myocardial infarction was analyzed.
  • hs-CRP levels were categorized into <1 mg/L, 1-3 mg/L, and >3 mg/L.
  • Cox proportional hazards regression models were used to assess associations after multivariate adjustment.

Main Results:

  • Elevated hs-CRP (≥1 mg/L) was associated with increased risks of all stroke and IS, but not ICH or SAH.
  • Specifically, hs-CRP 1-3 mg/L showed a hazard ratio (HR) of 1.17 for all stroke and 1.17 for IS.
  • hs-CRP >3 mg/L showed an HR of 1.25 for all stroke and 1.33 for IS.

Conclusions:

  • Higher hs-CRP concentrations are linked to an increased risk of IS, especially in non-fatal cases, males, and hypertensive individuals.
  • No significant association was found between hs-CRP and the risk of ICH or SAH.
  • hs-CRP may serve as a valuable biomarker for predicting IS risk in specific subgroups.