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Updated: Apr 24, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Total synthesis of (-)-bucidarasin a starting from an original chiral building block
Kenji Usui1, Misaki Kanbe, And Masahisa Nakada
1Department of Chemistry and Biochemistry, Faculty of Science and Engineering, Waseda University 3-4-1 Ohkubo , Shinjuku-ku, Tokyo 169-8555, Japan.
Abstract:
The highly stereoselective total synthesis of (-)-bucidarasin A, which also elucidated the absolute structure of its natural form, is described. The total synthesis features effective use of the original chiral building block prepared by us and a series of highly stereoselective reactions, i.e., hydroxy-directed hydrogenation, [4 + 2] cycloaddition of a sterically hindered dienophile, reduction of ketones, formation of the C9 side-chain diene, and formation of the THF moiety bearing two acetyloxy groups.
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