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Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

4.1K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

1.6K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Apr 24, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
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Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

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Liver stem cells, where art thou?

Markus Grompe1

  • 1Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Stem Cell Center, L 321, Oregon Health & Science University, Portland, OR 97239, USA.

Cell Stem Cell
|September 6, 2014
PubMed
Summary

New research challenges the long-held belief that facultative liver stem cells are the primary source of new hepatocytes during chronic liver injury, suggesting alternative mechanisms may be at play.

Area of Science:

  • Hepatology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • The prevailing theory posits facultative liver stem cells (FLSCs) as a key source for hepatocyte regeneration following chronic liver injury.
  • This model has guided research and therapeutic strategies for decades.

Purpose of the Study:

  • To critically evaluate the established paradigm of FLSC-mediated hepatocyte regeneration.
  • To present evidence from recent studies that question the dominant role of FLSCs in liver repair.

Main Methods:

  • Review and synthesis of findings from two key publications (Schaub et al., 2014; Yanger et al., 2014).
  • Analysis of experimental data pertaining to liver injury models and cell lineage tracing.

Main Results:

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Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination
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Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination

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Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells
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Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells

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Related Experiment Videos

Last Updated: Apr 24, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
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Isolation of CD133+ Liver Stem Cells for Clonal Expansion

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Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination
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Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells
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  • Evidence suggests that FLSCs may not be the principal source of new hepatocytes in chronic liver injury.
  • Alternative cellular sources or mechanisms of hepatocyte proliferation are indicated.

Conclusions:

  • The traditional understanding of liver regeneration requires re-evaluation.
  • Further research is necessary to elucidate the precise cellular dynamics governing hepatocyte replenishment in chronic liver disease.